2023

Copper-catalyzed Aminoazidation of Alkenes with NFC: One-step Vicinal Functionalization for CuAAC and SuFEx Reactions
Asian J. Org. Chem. 2023, Accepted Article

Difluorination of heterobenzylic C–H bonds with N-fluoro-N-(fluorosulfonyl)carbamate (NFC)
Akiya Adachi, Takuya Hashimoto, Kohsuke Aikawa, Kyoko Nozaki, Takashi Okazoe
Org. Chem. Front. 2023, 10, 5362-5368.

Olefin Difunctionalization With Two Different Atoms; 1,2-Aaminofunctionalization 1,2-Oxyfunctionalization With Non-halogen Function But B, S, Se
Takuya Hashimoto
Comprehensive Chirality, 2nd Ed.

2022

An N-Fluorinated Imide for Practical Catalytic Imidations
Yuno Oe, Ryuhei Yoshida, Airi Tanaka, Akiya Adachi, Yuichiro Ishibashi, Takashi Okazoe, Kohsuke Aikawa, Takuya Hashimoto
J. Am. Chem. Soc. 2022, 144, 2107–2113.

2021

Enantioselective Hydrative para-Dearomatization of Sulfonanilides by an Indanol-based Chiral Organoiodine Catalyst
Yuto Shimazaki, Chisato Wata, Takuya Hashimoto, Keiji Maruoka
Asian J. Org. Chem. 2021, 10, 1638-1642

Organoiodine-Catalyzed Enantioselective Intramolecular Oxyaminations of Alkenes with N-(Fluorosulfonyl)carbamate
Chisato Wata, Takuya Hashimoto
Synthesis 2021, 53, 2594-2601

Hyperpolarized ¹³C Magnetic Resonance Imaging of Fumarate Metabolism by Parahydrogen-induced Polarization: A Proof-of-Concept in vivo Study
Neil J. Stewart, Hitomi Nakano, Shuto Sugai, Mitsushi Tomohiro, Yuki Kase, Yoshiki Uchio, Toru Yamaguchi, Yujirou Matsuo, Tatsuya Naganuma, Norihiko Takeda, Ikuya Nishimura, Hiroshi Hirata, Takuya Hashimoto, Shingo Matsumoto
ChemPhysChem 2021, 22, 915-923

Organoiodine-Catalyzed Enantioselective Intermolecular Oxyamination of Alkenes
Chisato Wata, Takuya Hashimoto
J. Am. Chem. Soc. 2021, 143, 1745-1751.

2019

Scalable Synthesis of a Chiral Selenium pi-Acid Catalyst and Its Use in Enantioselective Iminolactonization of β,γ-Unsaturated Amides
Yuta Otsuka, Yuto Shimazaki, Hitoshi Nagaoka, Keiji Maruoka, Takuya Hashimoto
Synlett 2019, 30, 1679-1682.

2018

Indanol-Based Chiral Organoiodine Catalysts for Enantioselective Hydrative Dearomatization
Takuya Hashimoto, Yuto Shimazaki, Yamato Omatsu, Keiji Maruoka
Angew. Chem., Int. Ed. 2018, 57, 7200-7204.

Representative Publications Before 2018

A Bulky Thiyl-Radical Catalyst for the [3+2] Cyclization of N-Tosyl Vinylaziridines and Alkenes
Takuya Hashimoto, Takino Kohei, Hato Kazuki, Keiji Maruoka.
Angew. Chem., Int. Ed. 2016, 55, 8081-8085.

A Chiral Electrophilic Selenium Catalyst for Highly Enantioselective Oxidative Cyclization
Yu Kawamata, Takuya Hashimoto, Keiji Maruoka.
J. Am. Chem. Soc. 2016, 138, 5206-5209.

Boronic Acid-Catalyzed, Highly Enantioselective Aza-Michael Additions of Hydroxamic Acid to Quinone Imine Ketals
Takuya Hashimoto, Alberto Osuna Galvez, Keiji Maruoka.
J. Am. Chem. Soc. 2015, 137, 16016-16019.

Recent Advances of Catalytic Asymmetric 1,3-Dipolar Cycloadditions
Takuya Hashimoto, Keiji Maruoka.
Chem. Rev. 2015, 115, 5366-5412.

Catalytic Asymmetric Diels-Alder Reaction of Quinone Imine Ketals: A Site-Divergent Approach
Takuya Hashimoto, Hiroki Nakatsu, Keiji Maruoka.
Angew. Chem., Int. Ed. 2015, 54, 4617-4621.

A Catalytic Asymmetric Ugi-type Reaction With Acyclic Azomethine Imines
Takuya Hashimoto, Hidenori Kimura, Yu Kawamata, Keiji Maruoka.
Angew. Chem., Int. Ed. 2015, 51, 7279-7281.

An Organic Thiyl Tadical Catalyst for Enantioselective Cyclization
Takuya Hashimoto, Yu Kawamata, Keiji Maruoka.
Nat. Chem. 2014, 6, 702-705.

In Situ Assembled Boronate Ester Assisted Chiral Carboxylic Acid Catalyzed Asymmetric Trans-Aziridinations
Takuya Hashimoto, Alberto Osuna Galvez, Keiji Maruoka.
J. Am. Chem. Soc. 2013, 135, 17667-17670.

Axially Chiral Dicarboxylic Acid Catalyzed Activation of Quinone Imine Ketals: Enantioselective Arylation of Enecarbamates
Takuya Hashimoto, Hiroki Nakatsu, Yuka Takiguchi, Keiji Maruoka.
J. Am. Chem. Soc. 2013, 135, 16010-16013.

Catalytic Asymmetric Three-Component 1,3-Dipolar Cycloaddition of Aldehydes, Hydrazides, and Alkynes
Takuya Hashimoto, Yuka Takiguchi, Keiji Maruoka.
J. Am. Chem. Soc. 2013, 135, 11473-11476.

Phase-transfer-catalysed Asymmetric Synthesis of Tetrasubstituted Allenes
Takuya Hashimoto, Kazuki Sakata, Fumiko Tamakuni, Mark J. Dutton, Keiji Maruoka.
Nat. Chem. 2013, 5, 240-244.

Generation and Exploitation of Acyclic Azomethine Imines in Chiral Bronsted Acid Catalysis
Takuya Hashimoto, Hidenori Kimura, Yu Kawamata, Keiji Maruoka.
Nat. Chem. 2011, 3, 642-646.

Chiral Bronsted Acid-Catalyzed Asymmetric Trisubstituted Aziridine Synthesis Using alpha-Diazoacyl Oxazolidinones
Takuya Hashimoto, Hiroki Nakatsu, Kumiko Yamamoto, Keiji Maruoka.
J. Am. Chem. Soc. 2011, 133, 9730-9733.

Desymmetrizing Asymmetric Ring Expansion of Cyclohexanones with alpha-Diazoacetates Catalyzed by Chiral Aluminum Lewis Acid
Takuya Hashimoto, Yuki Naganawa, Keiji Maruoka.
J. Am. Chem. Soc. 2011, 133, 8834-8837.

Catalytic Asymmetric Alkynylation of C1-Substituted C,N-Cyclic Azomethine Imines by CuI/Chiral Bronsted Acid Co-Catalyst
Takuya Hashimoto, Masato Omote, Keiji Maruoka.
Angew. Chem., Int. Ed. 2011, 50, 8952-8955.

Asymmetric Inverse-Electron-Demand 1,3-Dipolar Cycloaddition of C,N-Cyclic Azomethine Imines: An Umpolung Strategy
Takuya Hashimoto, Masato Omote, Keiji Maruoka.
Angew. Chem., Int. Ed. 2011, 50, 3489-3492.

Catalytic Enantioselective 1,3-Dipolar Cycloaddition of C,N-Cyclic Azomethine Imines with alpha,beta-Unsaturated Aldehydes
Takuya Hashimoto, Yuko Maeda, Masato Omote, Keiji Maruoka.
J. Am. Chem. Soc. 2010, 132, 4076-4077.